Relationship between Intoxicating Dose,Blood Purification Method and Clinical Efficacy in Treatment of Acute Paraquat Poisoning

Objective To explore the clinical efficacy of blood purification in treatment of acute paraquat poisoning. Methods A total of 108 patients with acute paraquat poisoning were divided into four groups by different oral doses: group A( 5 ml),group B( 5-20 ml),group C( 20-50 ml) and group D( 20-50 ml). Each group was then divided into conventional group and intensive group according to different methods of blood purification. Fatality rates and changes of levels of arterial po2( PaO2),serous creatinine( Cr),aspartic transaminase( AST) on 1 D and 7 D after treatment were compared. Results Fatality rate of group D was significantly higher than those of other groups( P 0. 01). In the same group,fatality rate of intensive group was significantly lower than that of conventional group in group B and C( P 0. 01). In the same group,the PaO2level was significantly higher,and indexes of Cr and AST were significantly lower in intensive group on 7 D after treatment compared with those in conventional group in group B and C( P 0. 01); while there were no significant differences in index changes in group A and D by the two therapy methods. Conclusion There was a close relationship between intoxicating dose,blood purification method and clinical efficacy in treatment of acute paraquat poisoning.