Effect of Methylprednisolone on Kidney in Rats with Acute Paraquat Poisoning

Objective:To study the effect of different doses of methylpredmsolone on renal injury in rats with paraquat poisoning. Methods:120 Wistar rats were randomly divided into five groups:control group,exposed group and the intervention group(according to different doses of methylpredmsolone,divided into three groups).The other four groups were given intraperitoneal injection of paraquat (22mg/kg) except control group.Two hour later,according to group and body weight,inject methylprednisolone.At the first,third,and seventh day,6 experimental subjects were killed by drawing method to obtain the samples and observe the renal function and pathological changes.Results:Blood urea nitrogen(P= 0.0010.05) and creatinine(P=0.010.05)in each group were significantly different;5mg methylpredmsolone group was better than the others of the intervention group,which is significantly different with exposed group。Blood urea nitrogen(P=0.0070.05) and creatinine(P=0.0160.05) were significantly different at different time points, which was significantly lower than the third day of the seventh days.Pathological score in each group showed no significant difference(P = 0.210.05).Conclusion:Conclusion:Early using Glucocorticoids to treat PQ poisoning rats can significantly reduce the PQ poisoning caused by kidney damage and improve kidney function,especially lower doses of Glucocorticoids was significant difference,Effect of high-dose is not better than low-dose.