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2006•Unpublished venueRequires access

High mobility group box-1 protein and its role in sepsis

Fan Xue-gon

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Abstract

High mobility group box-1 protein locates nuclei and cytoplasm in normal condition.It involves in maintaining nucleosome structure and regulation of gene transcription.When immunocytes(i.e,monocytes and dendritic cells) are stimulated by LPS and cytokines,HMGB1 can be secreted into the extracellular milieu.It acts as proinflammatory cytokines,activates inflammatory responses.Being different from early proinflammatory cytokines(i.e,TNF-α and IL-1),HMGB1 is a late mediator in sepsis.HMGB1 plays an important role in sepsis,so it may be a convenient and practical index in evaluating severity of sepsis and may be an important and new therapeutic target in sepsis.The experimental study showed that anti-HMGB1 treatment could rescue animals from lethal sepsis.

About this research paper

What this paper is about

High mobility group box-1 protein locates nuclei and cytoplasm in normal condition.It involves in maintaining nucleosome structure and regulation of gene transcription.When immunocytes(i.e,monocytes and dendritic cells) are stimulated by LPS and cytokines,HMGB1 can be secreted into the extracellular milieu.It acts as proinflammatory cytokines,activates inflammatory responses.Being different from early proinflammatory cytokines(i.e,TNF-α and IL-1),HMGB1 is a late mediator in sepsis.HMGB1 plays an important role in sepsis,so it may be a convenient and practical index in evaluating severity of sepsis and may be an important and new therapeutic target in sepsis.The experimental study showed that anti-HMGB1 treatment could rescue animals from lethal sepsis.

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Available abstract

High mobility group box-1 protein locates nuclei and cytoplasm in normal condition.It involves in maintaining nucleosome structure and regulation of gene transcription.When immunocytes(i.e,monocytes and dendritic cells) are stimulated by LPS and cytokines,HMGB1 can be secreted into the extracellular milieu.It acts as proinflammatory cytokines,activates inflammatory responses.Being different from early proinflammatory cytokines(i.e,TNF-α and IL-1),HMGB1 is a late mediator in sepsis.HMGB1 plays an important role in sepsis,so it may be a convenient and practical index in evaluating severity of sepsis and may be an important and new therapeutic target in sepsis.The experimental study showed that anti-HMGB1 treatment could rescue animals from lethal sepsis.

Key concepts: HMGB1, Proinflammatory cytokine, Sepsis, High-mobility group, Mediator, Immunology, Inflammation, Tumor necrosis factor alpha

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