Investigation Progress of the Correlation between HMGB1 and Sepsis

High mobility group box 1 protein(HMGB1),an abundant,highly conserved cellular protein,is widely known as a nuclear DNA-binding protein that stabilizes nucleosome formation,and facilitates gene transcription.Recent studies suggested that HMGB1 could be overexpressed and released from celluar nucleosome upon endotoxin and proinflammatory cytokines stimulation,or other stress challenge including burns,shock,as well as infection and participat in course of sepsis as a crucial late mediator.The delayed kinetics of HMGB1 release suggested that it can be a potential drug target and targeted in a wider therapeutic window than is provided by inhibitors that target the early cytokine.This paper reviewed the correlation between HMGB1 and sepsis.