Relationship between bone metabolic biochemical markers of osteoporosis and bone mineral density

Objective To study the relationship between bone density and change of bone metabolism biochemical markers of osteoporosis, thereky differentiating osteoporotic patients with different bone metabolic levels and guiding clinical medication. Methods Sixty-five osteoporosis patients (27 men, 38 women) Blood tests for BGP, ALP-B and CTX, and bone density measurement by dual energy X-ray absorptiometry (Norland, USA), using the special software developed by Beijing Ji Shui Tan Hospital; the diagnosis of osteoporosis ectablished when BMD≤-2.0 SD, and secondary Osteoporosis was excluded. Twenty-seven healthy subjects as normal controls underwent the same tests. Results The bone density of osteoporoic patients in various parts of the body was significomtly lower than that of the confrols. Blood BGP level was significanfly higher than that in the control group but the ALP-B and CTX did not show much differece. Among the biochemical markers of the osteoporotic patients, only ALP-B was closely relatied to the bone density of femoral neck and Ward's triangle. BGP and CTX did not show much connection with the bone density in other parts of the body. CTX had some relationship to Ward's triangle bone desity only in the healthy untrol group. Conclusions Bone metabolism biochemical markers is an effective means for evaluating bone Turn-over; combined with bone density measurement, it can properly and fully evaluate bone furn-over, rete, facilitating individualized treatment of osteoporosis. Sine there are no diffesenus in a number of bone metabolic biochemical markers between osteoporotic patients and healthy confrals these indices are not useful for diagnosis and differentiation of osteoporosis except for evahcation of therapeutic results.