Comparison of Serum CYFRA21-1,NSE and CEA,Levels in Patients with Different Pathological Types of Lung Cancer

Objective:To discuss the value of combined detection of serum CYFRA21-1,NSE and CEA for the diagnosis of different pathological types of lung cancer.Methods:Serum CYFRA21-1,NSE and CEA were measured by chemiluminescence in 45 cases of lung adenocarcinoma,42 cases of lung squamous carcinoma and 43 cases of small cell lung cancer.Results:In CYFRA21-1detection,the group of lung squamous carcinoma had the highest level,the lung adenocarcinoma group was the second,the lowest was in the small cell lung cancer group,and there is statistical difference among the three groups(F=5.842,P0.05),While the detection level of CYFRA21-1had no obvious correlation with lung cancer TNM staging(P0.05).In NSE detection,small cell lung cancer group had the highest NSE content,which was(18.76±12.31)ng/ml(P0.01),while there was no significant difference in NSE content bewteen lung adenocarcinoma and lung squamous carcinoma(P0.05).The NSE content in patients withⅠ/Ⅱstaging lung cancer was significantly higher than that in patients withⅢ/Ⅳstaging lung cancer(P0.05).In CEA detection,the CEA content in lung adenocarcinoma group was(89.45±34.58)ng/ml,which was significantly higher than that in lung squamous carcinoma group and small cell lung cancer group(P0.01).The CEA content in patients with Ⅲ/Ⅳ staging lung cancer was significantly higher than that in patients withⅠ/Ⅱstaging lung cancer(P0.05).Compared with single detection and two joint detection,there was no obvious specificity decline in three joint detection(P0.05),and the sensitivity and accuracy increased to 80.00%and 81.97%respectively,the difference is statistically significant(P0.05).Conclusion:The combined detection of tumor markers CYFRA21-1,NSE,and CEA can improve the detection sensitivity and accuracy of lung cancer,at the same time provide reliable reference basis for lung cancer diagnosis which can not be done by the pathological examination.