2011•Zhongguo shiyan fangjixue zazhiRequires access
Optimization of Ultrasound Extraction Process of Total Flavonoids from Agrimonia pilosa by Response Surface Methodology
Xiuquan Xu
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Abstract
Objective: To optimize optimum ultrasound extraction process of total flavonoids from Agrimania pilosa.Method: With yield of total flavonoids as index,ethanol concentration,ultrasound temperature and material-liquid ratio were optimized by response surface methodology(RSM).Result: Effect factors on extraction rate of total flavonoids with the order of follows: material-liquid ratio,ultrasound temperature,ethanol concentration.The optimal extraction conditions were ethanol concentration was 72%,material-liquid ratio of 1∶25,extraction temperature was 60 ℃,extraction time was 20 min.Under these conditions,yield of total flavonoids reached 9.02 mg·g-1,which was agreed with model prediction.Conclusion: This extraction process of total flavonoids from A.pilosa by ultrasound-assisted was stable and reliable.