Investigation on Bioactivity of Glass Based Bone Cement

Glass based bone cement (GBC) was synthesized by mixing CaO-SiO_2-P_2O_5 based glass powder with ammonium phosphate liquid.Phase structure,chemical composition and microstructure of the final products of GBC were measured and observed using X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR) and scanning electron microscopy (SEM) respectively.The results show that with a longer immersion time in simulated body fluid (SBF),the glass phase in GBC gradually changed to hydroxyapatite(HAP).It is also indicated that the crystal formed in GBC belongs to a bone-like hydroxya-canbonate apatite crystallite with the end plane granularity 30～50 nm.Participation of structural carbonate into HAP crystal structure was demonstrated by FTIR.HAP produced in GBC has great similarity in crystal morphology,structure and composition with natural bone HAP.GBC seems to be a greatly desirable biomedical material with high bioacitvity.