Different dosage regimens of remifentanil,lidocain and propofol for tracheal intubation without muscle relaxants

Objective The study was designed to compare the intubating conditions and haemodynamic responses without muscle relaxants following different dosage regimens of remifentanil,lidocaine and propofol.Methods 80 healthy patients were assigned to four groups,including Group Ⅰ treated with remifentanil 3μg/kg and propofol 2 mg/kg,Group Ⅱ treated with remifentanil 3μg/kg,lidocaine 1.5 mg/kg and propofol 2 mg/kg,Group Ⅲ treated with remifentanil 4μg/kg and propofol 2 mg/kg,and Group Ⅳ treated with remifentanil 3μg/kg and propofol 3 mg/kg.Groups Ⅰ,Ⅲ,and Ⅳ were given same volume of 0.9% saline instead of lidocaine in Group Ⅱ.The intubating conditions were assessed as excellent,good or poor.Mean arterial pressure(MAP) and heart rate(HR) were recorded before induction,postinduction,immediately after intubation,and three and five minutes after intubation.Results Satisfactory intubation conditions in Group I were significantly better than that in Group Ⅱ,Ⅲ,and Ⅳ(P﹤0.05).Significant reductions in MAP and HR after administration were observed in each group(P﹤0.05).Conclusion The coadministration of remifentanil 3μg/kg,lidocaine 1.5 mg/kg,and propofol 2 mg/kg may reliably provide adequate conditions for tracheal intubation with less hemodynamic suppression in healthy patients without muscle relaxants.