Improvement on: Preparation of Gelatin Microspheres

The preparation of gelatin microspheres is one of the contents in pharmaceutics experiment courses. However,the microspheres prepared by original method are usually adhesive,too small in particle size,and the preparation efficiency is relatively low. To improve the outcome of experimental class study,the original method for preparation of gelatin microspheres were adjusted in this study. New formulation and process were applied,including the change of oil phase,the concentration and usage of gelatin solution,water-oil ratio,and a different kind of cross-linking agent. In addition,the order of mixing each component was adjusted,as well as the manner of dehydration washing. As a result,the microspheres prepared by the new method showed better properties: transparent and spherical with good appearance,dispersed well and with proper particle size. Furthermore,the amount of microspheres prepared and the preparation efficiency both increased.