Study on expression and clinical significance of NF-κBp 65 and caspase 8 in gastric carcinoma

Objective:To investigate the protein expressions of NF-κBp 65 and caspase 8 in gastric carcinoma tissues and their relationship with clinicolpathological features.Methods:NF-κBp65 protein and caspase 8 protein were determined in 60 cases of gastric carcinoma by immunohistochemistry PV-9000.Results:The positive rate of NF-κBp65 protein expression was 63.3% in gastric carcinoma tissues,higher than 30.0% in adjacent non-cancerous tissues(P0.05),the positive rate of caspase 8 protein expression was 35.0% in gastric carcinoma tissues,lower than 83.3% in adjacent non-cancerous tissues(P0.05);the expression of NF-κBp65 in poorly-differentiated adenocarcinoma was higher than that in well-differentiated adenocarcinoma(P0.05),but the expression of caspase 8 in poorly-differentiated adenocarcinoma was lower than that in well-differentiated adenocarcinoma(P0.05);and the increased expression of NF-κBp65 significantly correlated with infiltrative depth,lymph node metastasis(P0.05).The expression level of caspase 8 only was correlated with differentiation of gastric carcinoma;a negative correlation also was founded between NF-κBp 65 and caspase 8(P0.05).Conclusion:NF-κBp65 and caspase 8 may be involved in apotosis of gastric carcinoma and play an essential role in carcinogenesis.NF-κBp65 may have negative regulation on caspase8 in gastric carcinoma.