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Compared study on DNA ploidy analysis and exfoliative cytologic examination in diagnosis of malignant pleural effusion and ascites

Yinsheng Li

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Abstract

Objective To compare the value of DNA ploidy analysis by DNA image cytometry( ICM-DNA) and exfoliative cytologic examination in diagnosis of malignant pleural effusion and ascites. Methods ICM-DNA and exfoliative cytology were used to detect one hundred and fifty-eight patients with peural effusion and ascites and their sensitivity and specificity were compared. Results The sensitivity of ICM-DNA and exfoliative cytology were 72. 50% ( 58 /80) ,47. 50% ( 38 /80) respectively,there was significant difference between them ( P 0. 01) . The specificity of ICM-DNA and exfoliative cytology were 93. 59%( 73 /78) ,96. 15% ( 75 /78) respectively,there was no significant difference ( P 0. 05) . Conclusion The combination of ICM- DNA ploidy analysis and exfoliative cytologic examination can provide the great significance for differential diagnosis of malignant pleural effusion and ascites.

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Objective To compare the value of DNA ploidy analysis by DNA image cytometry( ICM-DNA) and exfoliative cytologic examination in diagnosis of malignant pleural effusion and ascites. Methods ICM-DNA and exfoliative cytology were used to detect one hundred and fifty-eight patients with peural effusion and ascites and their sensitivity and specificity were compared. Results The sensitivity of ICM-DNA and exfoliative cytology were 72. 50% ( 58 /80) ,47. 50% ( 38 /80) respectively,there was significant difference between them ( P 0. 01) . The specificity of ICM-DNA and exfoliative cytology were 93. 59%( 73 /78) ,96. 15% ( 75 /78) respectively,there was no significant difference ( P 0. 05) . Conclusion The combination of ICM- DNA ploidy analysis and exfoliative cytologic examination can provide the great significance for differential diagnosis of malignant pleural effusion and ascites.

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Available abstract

Objective To compare the value of DNA ploidy analysis by DNA image cytometry( ICM-DNA) and exfoliative cytologic examination in diagnosis of malignant pleural effusion and ascites. Methods ICM-DNA and exfoliative cytology were used to detect one hundred and fifty-eight patients with peural effusion and ascites and their sensitivity and specificity were compared. Results The sensitivity of ICM-DNA and exfoliative cytology were 72. 50% ( 58 /80) ,47. 50% ( 38 /80) respectively,there was significant difference between them ( P 0. 01) . The specificity of ICM-DNA and exfoliative cytology were 93. 59%( 73 /78) ,96. 15% ( 75 /78) respectively,there was no significant difference ( P 0. 05) . Conclusion The combination of ICM- DNA ploidy analysis and exfoliative cytologic examination can provide the great significance for differential diagnosis of malignant pleural effusion and ascites.

Key concepts: Exfoliative cytology, Ascites, Cytology, Malignant pleural effusion, Medicine, Pleural effusion, Pathology, Effusion

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Compared study on DNA ploidy analysis and exfoliative cytologic examination in diagnosis of malignant pleural effusion and ascites — Research Paper | ScholarLens