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2007•Acta Academiae Medicinae Qingdao UniversitatisRequires access

COMBINED THERAPY OF PGE_1 AND LOSARTAN FOR PROTEINURIA IN PATIENTS WITH INCIPIENT DIABETIC NEPHROPATHY

Jing Sun

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Abstract

Objective To observe the effect of prostaglandin E1(PGE1)and Losartan on proteinuria in patients with early diabetic nephropathy(DN).Methods Fifty-five patients with incipient DN were divided randomly into two groups:treatment group(n=25)and control group(n=27).The control group was given 100 mg Losartan daily;the treatment group,100 mg Losartan plus 20 μg PGE1 daily.Two 14-day courses of treatment were separated by a two-week interval.The relative indexes between the two groups were observed and compared.Results In the treatment group,24 hours UAER was significantly reduced after treatment as compared with before treatment as well as with the control group(t=4.36,P0.01).Conclusion The prostaglandin E1 combined with Losartan may decrease proteinuria in patients with incipient diabetic nephropathy,which has no harmful effects on renal function and blood sugar.

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What this paper is about

Objective To observe the effect of prostaglandin E1(PGE1)and Losartan on proteinuria in patients with early diabetic nephropathy(DN).Methods Fifty-five patients with incipient DN were divided randomly into two groups:treatment group(n=25)and control group(n=27).The control group was given 100 mg Losartan daily;the treatment group,100 mg Losartan plus 20 μg PGE1 daily.Two 14-day courses of treatment were separated by a two-week interval.The relative indexes between the two groups were observed and compared.Results In the treatment group,24 hours UAER was significantly reduced after treatment as compared with before treatment as well as with the control group(t=4.36,P0.01).Conclusion The prostaglandin E1 combined with Losartan may decrease proteinuria in patients with incipient diabetic nephropathy,which has no harmful effects on renal function and blood sugar.

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Available abstract

Objective To observe the effect of prostaglandin E1(PGE1)and Losartan on proteinuria in patients with early diabetic nephropathy(DN).Methods Fifty-five patients with incipient DN were divided randomly into two groups:treatment group(n=25)and control group(n=27).The control group was given 100 mg Losartan daily;the treatment group,100 mg Losartan plus 20 μg PGE1 daily.Two 14-day courses of treatment were separated by a two-week interval.The relative indexes between the two groups were observed and compared.Results In the treatment group,24 hours UAER was significantly reduced after treatment as compared with before treatment as well as with the control group(t=4.36,P0.01).Conclusion The prostaglandin E1 combined with Losartan may decrease proteinuria in patients with incipient diabetic nephropathy,which has no harmful effects on renal function and blood sugar.

Key concepts: Losartan, Medicine, Proteinuria, Diabetic nephropathy, Urology, Prostaglandin E1, Renal function, Internal medicine

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COMBINED THERAPY OF PGE_1 AND LOSARTAN FOR PROTEINURIA IN PATIENTS WITH INCIPIENT DIABETIC NEPHROPATHY — Research Paper | ScholarLens