Effect of Xuebijing injection on oxygen radicals in rats with acute lung injury

Objective To investigate the effect of Xuebijing injection(XBJ) on oxygen radicals in rats with acute lung injury.Methods Acute lung injury model was established in 64 rats by intravenous lipopolysaccharide(LPS, 5 mg / kg) injection, and then were assigned to receive intraperitoneal 10 mL/ kg normal saline injection(LPS group, including 1 h, 2 h, 4 h, and 12 h subgroups, each n = 8) or intraperitoneal 10 mL / kg XBJ injection(LPS + XBJ group, including 1 h,2 h,4 h, and 12 h subgroups, each n = 8).Another 8 normal rats received intravenous normal saline injection as control group.Pathological changes of lung tissue were observed, the levels of malondialdehyde(MDA) and superoxide dismutase(SOD) were measured, and the W / D lung weight ratio was calculated.Results The W / D lung weight ratio and MDA level were significantly increased in LPS group as compared with those in control group and LPS + XBJ group(P 0.01 or P 0.05), SOD level was decreased significantly in LPS group as compared with those in control group and LPS + XBJ group(P 0.01 or P 0.05).Histopathological examination showed that the degree of lung injury in LPS + XBJ group was less severe than that in LPS group.Conclusion XBJ can protect the lung from damage induced by LPS in rats by decreasing oxygen radicals.