Effect of valsartan and benazepril on myocardial remodeling in renal hypertensive rats

Objective To investigate the effect of valsartan and benazepril on myocardial remodeling of renal hypertensive rats.Methods Renal hypertension model were induced in Sprague Dawley(SD) rats by two kidney with one clip method.24 rats were randomly allocated to the following groups:placebo group(n = 8),valsartan group(30 mg·kg~(-1)·d~(-1),n =8),benazepril group(10 mg·kg~(-1)·d~(-1),n =8),another 8 rats as sham operation group(n =8).Eight weeks after intra-gastric administration,left ventricular mass index(LVMI) was calculated,after HE and Masson staining,collagen volume fraction(CVF) and perivascular collagen area(PVCA) were measured.Results The blood pressure(BP),LVMI, CVF and PVCA were increased in rats of disease model groups,cardiac hypertrophy and myocardial fibrosis were also obvious in these groups.Both valsartan and benazepril can reduce the degree of cardiac hypertrophy,myocardial fibrosis,BP,LVMI, CVF and PVCA(P0.05,P0.01 ).But no significant difference was found between valsartan and benazepril(P0.05).Conclusion Valsartan and benazepril have regressive effect on cardiac remodeling,but no significant difference was found between the two drugs.