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2011•Laboratory Medicine and ClinicRequires access

Analysis of false positive results by ELISA analysis in elderly syphilis

HE Lan-hui

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Abstract

Objective To analyze the false positive results of syphilis antibodies detected by ELISA in elderly patients with syphilis and to study their relation with clinic.Methods TP-ELISA was used to detect anti-syphilis specific antibody in 2454 cases of syphilis aged more than 60 years and 12,545 cases of syphilis aged less than 60 years in our hospital from January 2007 to January 2010,those with positive results were redetected by TPPA.Results The false-positive rate of ELISA-TP in the patients aged over 60 was significantly higher than that in the patients aged less than 60 with statistical difference between the two groups(P0.05).Conclusion The reagent itself,human hosts-related spirochetes,basic diseases are the the major reasons easily causing the false positive results of TP-ELSA in elderly syphilis.Should prevent misdiagnosis to result in medical disputes.

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What this paper is about

Objective To analyze the false positive results of syphilis antibodies detected by ELISA in elderly patients with syphilis and to study their relation with clinic.Methods TP-ELISA was used to detect anti-syphilis specific antibody in 2454 cases of syphilis aged more than 60 years and 12,545 cases of syphilis aged less than 60 years in our hospital from January 2007 to January 2010,those with positive results were redetected by TPPA.Results The false-positive rate of ELISA-TP in the patients aged over 60 was significantly higher than that in the patients aged less than 60 with statistical difference between the two groups(P0.05).Conclusion The reagent itself,human hosts-related spirochetes,basic diseases are the the major reasons easily causing the false positive results of TP-ELSA in elderly syphilis.Should prevent misdiagnosis to result in medical disputes.

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Available abstract

Objective To analyze the false positive results of syphilis antibodies detected by ELISA in elderly patients with syphilis and to study their relation with clinic.Methods TP-ELISA was used to detect anti-syphilis specific antibody in 2454 cases of syphilis aged more than 60 years and 12,545 cases of syphilis aged less than 60 years in our hospital from January 2007 to January 2010,those with positive results were redetected by TPPA.Results The false-positive rate of ELISA-TP in the patients aged over 60 was significantly higher than that in the patients aged less than 60 with statistical difference between the two groups(P0.05).Conclusion The reagent itself,human hosts-related spirochetes,basic diseases are the the major reasons easily causing the false positive results of TP-ELSA in elderly syphilis.Should prevent misdiagnosis to result in medical disputes.

Key concepts: Syphilis, Medicine, Syphilis Serodiagnosis, Immunology, Internal medicine, Human immunodeficiency virus (HIV)

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