Sedation Effects of Target-controlled Infusion of Propofol or Midazolam on Patients with Intracranial Aneurysms during Endovascular Treatment

Objective To investigate the feasibility of target-controlled infusion(TCI) of propofol or midazolam for sedation in patients with intracranial aneurysms undergoing endovascular treatment.Methods Forty patients(Hunt-Hess grades 0～ Ⅱ) with intracranial aneurysms undergoing endovascular treatment were randomly divided into both propofol group(n=20),where the patients received TCI of propofol,and midazolam group(n=20),where the patients received TCI of midazolam.The 1evel of sedation was evaluated by observer's assessment of alertness/sedation(OAA/S) scale.Target concentration(Ct) and effect concentration(Ce),mean arterial pressure(MAP),heart rate(HR),SpO2,bispectral index(BIS) and satisfaction of sedation in all the patients were recorded.Results With the decrease in the OAA/S score,MAP,HR and SpO2 also decreased significantly in both the groups(P0.05).And with the increase in Ct and Ce,the depth of the sedation increased gradually,and the OAA/S scores and BIS dropped(P 0.05).The induction phase and time from sedation to analepsia were significantly shorter in propofol group than these in midazolam group(P 0.05).Conclusions TCI of propofol or midazolam may be used for conscious sedation in patients with intracranial aneurysms undergoing endovascular treatment,but TCI of propofol has the advantages such as easy control of appropriate sedation and the higher levels of cooperation of the patients with the surgeons compared to TCI of midazolam.