COMPARISON OF TARGET-CONTROLLED INFUSION WITH PROPOFOL AND MIDAZOLAM FOR SEDATION IN PATIENTS UNDERGOING EPIDURAL ANESTHESIA

ObjectiveTo compare target controlled infusion(TCI) with propofol and midazolam for sedation in patients undergoing epidural anesthesia and to provide instruction of clinical application.MethodsForty patients undergoing lower-abdominal operation under epidural anesthesia were randomly divided into two equal groups.Group Ⅰ combined TCI with propofol;Group Ⅱ with midazolam only.After anesthesia,TCI was executed.OAA/S score and BIS were used to monitor sedation of patients.MAP,HR,SpO_2,BIS and plasma concentration were recorded as OAA/S score changed.OAA/S score was kept on 3(during) operation.The score would be reduced to 2 if body moving observed.Adverse reactions were monitored during operation.TCI was stopped before the end of operation and awake time recorded.ResultsThe changes of MAP,HR,SpO_2,and BIS in different OAA/S score were observed in the two groups,but no significant difference found between them.The adverse reactions were not different between two groups.Awake time of Group Ⅰ was significantly shorter than Group Ⅱ(t=5.15,P0.05).There was a positive correlation between OAA/S score and BIS,and negative correlation between BIS and plasma concentration.(ConclusionTCI with) propofol and midazolam for sedation in patients undergoing epidural anesthesia is safe and effective.BIS and OAA/S score can be used to direct TCI.