Effects of perindopril and spironolactone on cardiovascular remodeling and fibrinolysis system in hypertensive rats

Objective To investigate the effects of perindopril and spironolactone on cardiovascular remodeling and fibrinolysis system in experimental hypertensive rats.Methods The models of hypertensive rat were established by using the method of abdominal aortic coarctation.The 44 male Wistar rats were randomly divided into 4 groups:hypertension model group,perindopril group(hypertensive rats subjected to perindopril,2mg·kg- 1·d- 1),spironolactone group(hypertensive rats receiving spironolactone,20mg · kg- 1· d- 1),sham-operation group(control group),with 11 rats in each group.After 12-week treatment,the cardiac and aortic structure and function of the rats were examined by ultrasonography,meanwhile,aortic morphous was observed,and the levels of plasma tissue plasminogen activator(t-PA) and plasminogen activator inhibitor(PAI-1) were detected.Results As compared with those in hypertension model group,interventricular septal thickness(IVSTd),left ventricular posterior wall thickness(LVPWTd),relative wall thickness(RWT) of left ventricular,left ventricular mass(LVM),left ventricular end-diastolic diameter(LVEDD),left atrial diameter(LVD) and the thickness of aorta in perindopril group and spironolactone group were significantly decreased(P0.01 or P 0.05); the media thickness of aorta,the ratio of media thickness to diameter of lumen aorta were obviously decreased(P0.01).The plasma levels of PAI-1 in perindopril group and spironolactone group were significantly increased,as compared with those in control group(P0.01),however,there were no significant differences in plasma levels of PAI-1 between the two drug groups and hypertension model group(P0.05).There were no significant differences in t-PA levels among the four groups(P0.05).Conclusion Hypertension can resulte in cardiovascular remodeling and hypofibrinolysis,both perindopril and spironolactone can reverse cardiovascular remodeling,however,they do not have obvious reverse effect on fribrinolysis.