Expresstion of survivin in breast carcinoma and its relationship with Caspase-3 and clinical factors

Objective To investigate the expression of survivin and its relationship with Caspase-3 and clinical factors in breast carcinoma.Methods Survivin and Caspase-3/CerbB-2/Ki67/p53/ER/PR expressions were detected by immuohistochemisitry in the normal breast tissues,14 cases),proliferative breast disease (epithelial hyperplasia,14 cases),breast preinvasive carcinoma (20 cases) and breast invasive carcinoma (52 cases).Results The positive rates of survivin expressin were 21.4%,35.7%,60.0% and 71.2% in the four groups,respectively(P0.05).Survivin expression was related to lymphnode metastasis(P0.05).The expressin of Caspase-3 was negatively correlated with the expression of survivin (P0.05).The Ki67/p53 indexes were significantly higher in survivin positive tumors (48.57±23.07)/(32.76±33.37) than those in the negative ones (21.30±20.50)/(15.43±24.44) (P0.05).Conclusion The overexpression of survivin may play an important role in the pathogenesis and progress of breast carcinoma by the way of inhibition of the active Caspase-3 and of the accelerating proliferation.Survivin may be served as a new target for apoptosis-inducing therapy for breast carcinoma.