ScholarLens Back to search
2011•Chinese Journal of AIDS & STDRequires access

The research progress in HAART-related hyperlactacidemia/lactic acidosis in HIV/AIDS patients

Hongxi Zhao

Open publisher page 0 citations

Abstract

Since HAART are taken in AIDS patients in developing countries,the morbidity and mortality of opportunistic infections have been significantly reduced.Since 2003,free HAART treatment have been carried out with support of the Chinese government,in which nucleoside analogs such as stavudine,zidovudine or didanosine are treated as backbone.The main side effect of nucleoside analogs is mitochondrial toxicity,resulting in hyperlactacidemia/lactic acidosis.In this review,we have summarized the incidence,mechanisms,clinical manifestations,diagnosis,treatment and prognosis of hyperlactacidemia/lactic acidosis in HIV/AIDS patients.

About this research paper

What this paper is about

Since HAART are taken in AIDS patients in developing countries,the morbidity and mortality of opportunistic infections have been significantly reduced.Since 2003,free HAART treatment have been carried out with support of the Chinese government,in which nucleoside analogs such as stavudine,zidovudine or didanosine are treated as backbone.The main side effect of nucleoside analogs is mitochondrial toxicity,resulting in hyperlactacidemia/lactic acidosis.In this review,we have summarized the incidence,mechanisms,clinical manifestations,diagnosis,treatment and prognosis of hyperlactacidemia/lactic acidosis in HIV/AIDS patients.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Since HAART are taken in AIDS patients in developing countries,the morbidity and mortality of opportunistic infections have been significantly reduced.Since 2003,free HAART treatment have been carried out with support of the Chinese government,in which nucleoside analogs such as stavudine,zidovudine or didanosine are treated as backbone.The main side effect of nucleoside analogs is mitochondrial toxicity,resulting in hyperlactacidemia/lactic acidosis.In this review,we have summarized the incidence,mechanisms,clinical manifestations,diagnosis,treatment and prognosis of hyperlactacidemia/lactic acidosis in HIV/AIDS patients.

Key concepts: Didanosine, Lactic acidosis, Stavudine, Medicine, Acidosis, Zidovudine, Human immunodeficiency virus (HIV), Nucleoside analogue

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The research progress in HAART-related hyperlactacidemia/lactic acidosis in HIV/AIDS patients — Research Paper | ScholarLens