Etiology analysis of hand- foot- mouth disease in Ningbo in 2012

Objective To explore the etiology characteristics of hand foot and mouth disease( HFMD) in Ningbo. Methods Fluorescent quantitative RT- PCR was used to detect viral nucleic acid of enterovirus 71,Coxakivirus 16 and other enteroviruses in samples from HFMD cases,who were clinically diagnosed in sentinel surveillance hospitals in Ningbo. Results Nine hundred and ten cases were detected enterovirus in total 1136 specimens,the total positive rate was 80. 11%,including 288 enterovirus 71 cases( 31. 65%),330 Coxakivirus 16 cases( 36. 26%) and 292 other enteroviruses cases( 32. 09%). The composition of pathogens was different among different months,both the total enterovirus positive rates and proportion of enterovirus types had no statistical significance in different age groups( P 0. 05). Male- female sex ratio in laboratory diagnosis cases was 1. 54∶1. In 61 other enterovirus cases,most were Coxakivirus 6 and Coxaki- virus 10,accounting for 44. 26% and 18. 03% respectively. Conclusion The major pathogen of HFMD was Cox A16 in Ningbo in 2012,followed by EV71,and other enteroviruses show a rising trend,so further typing detection should be strengthened in HFMD cases.