2004•Zhongguo linchuang yaolixue yu zhiliaoxueRequires access
Effects of caffeic acid,ferulic acid and vanillic acid on tyrosinase
Li Chang
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Abstract
AIM: To evaluate the effects of monomers of caffeic acid, ferulic acid and vanillic acid on the activity of tyrosinase, so as to provide a kind of drug in the treatment of hyperpigmentation. METHODS: Tyrosinase activity was estimated by measuring the oxidation rate of L DOPA. The inhibitory pattern of each monomer was determined according to their Lineweaver Burk curve compared to the controlled group. RESULTS: Vanillic acid showed an inhibition to tyrosinase activity, and the rate of inhibitory was similar to hydroquinone, which had no statistically significant difference between them (P 0.05 ). Caffeic acid and ferulic acid showed an up regulation to tyrosinase activity. CONCLUSION: Vanillic acid, a mixed type inhibitor of tyrosinase, can inhibit the activity of tyrosinase greatly.