Effect of iron malnutrition during pregnancy on serum lipids and lipid peroxidation in adult offspring rats

Objective:To investigate the effect and Intervention of low iron during pregnancy on lipid peroxidation and blood lipids of its offspring in adulthood through establish a nutritional iron deficient model with pregnancy rats.Methods: Healthy female Wistar rats were randomly divided into two groups(control group and ID group),The rats in experimental group and control group were fed on low iron or normal diet respectively.experimental group were fed low iron diet(iron 7.4 mg/kg),control group was fed with iron diet(iron 274 mg/kg).And healthy adult Wistar male rats were mated 2 weeks after the same Iron intervention began to offspring when transferred to 23 weeks after the birth of ordinary particles that iron balance of diet for 8 months,measuring of plasma triglyceride(TG),total cholesterol(TC),low density lipoprotein(LDL)、high density lipoprotein(HDL)、lipoprotein a 、free fatty acid(FFA),serum superoxide dismutase(SOD) activity and malondialdehyde(MDA).Results: Compared with the control group,ferritin(SF)、FFA、SOD increased,HDLdecreased(P0.05);Conclusion: Malnutrition during pregnancy can result in iron on lipid metabolism in adult rats decreased ability to regulate,there dyslipidemia,promote,while SOD activity of antioxidant enzymes increased.