Comparability analysis between dry chemistry analyzer and wet chemistry analyzer

Objective To investigate the comparability of the results of 16 routine biochemical indexes detected by different biochemical analyzers.Methods With the Beckman DXC800 automatic biochemical analyzer as the reference system and the VITROS5600 automatic biochemical immune analyzer as the compared system according to the EP9-A2,guideline established by NCCLS.The 16 routine biochemical indexes were detected in serum of patients by the two instruments.The clinical acceptability of the VITROS5600 dry chemistry system was evaluated according to the judgment basis of 1/2allowable error of the external quality assessment in CLIA′88standard.Results The reference system and the compared system had better comparability.All tests showed good correlation between the two analytical systems.The biases of all tests were clinically acceptable,except for ALT,LDH,Crea,AST,Ca and TP.Conclusion The VITROS5600 dry chemical instrument could have good comparability with the Beckman DXC800 automatic biochemical analyzer.But the biases of ALT,AST,LDH,Ca and Crea and TP in the clinical comparison at multiple levels were not acceptable.It is necessary to establish the different reference ranges aiming at different methods.