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2011•Jiangsu Medical JournalRequires access

A preliminary study on the genesis of Jagged1 mRNA in astrocyte induced by TGF-β1

GU Bingjie

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Abstract

Objective To investigate the effect of TGF-β1 on the genesis of Jagged1 mRNA in astrocyte.Methods After the astrocyte activated by LPS was cultivated with TGF-β1 for 24 hours,the Jagged1 mRNA was extracted.The expression of Jagged1 mRNA was evaluated at 0,6,12 and 24 h.Results TGF-β1 induced the expression of Jagged1 mRNA in astrocyte.As culture duration extended,the expression of Jagged1 mRNA was attenuated significantly(P0.05).Conclusion TGF-β1 can induce the expression of Jagged1 mRNA in the LPS-activated astrocyte,which may inhibit the repair of myelin sheath through the activation of Jagged1/Notch1 pathway.

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What this paper is about

Objective To investigate the effect of TGF-β1 on the genesis of Jagged1 mRNA in astrocyte.Methods After the astrocyte activated by LPS was cultivated with TGF-β1 for 24 hours,the Jagged1 mRNA was extracted.The expression of Jagged1 mRNA was evaluated at 0,6,12 and 24 h.Results TGF-β1 induced the expression of Jagged1 mRNA in astrocyte.As culture duration extended,the expression of Jagged1 mRNA was attenuated significantly(P0.05).Conclusion TGF-β1 can induce the expression of Jagged1 mRNA in the LPS-activated astrocyte,which may inhibit the repair of myelin sheath through the activation of Jagged1/Notch1 pathway.

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Available abstract

Objective To investigate the effect of TGF-β1 on the genesis of Jagged1 mRNA in astrocyte.Methods After the astrocyte activated by LPS was cultivated with TGF-β1 for 24 hours,the Jagged1 mRNA was extracted.The expression of Jagged1 mRNA was evaluated at 0,6,12 and 24 h.Results TGF-β1 induced the expression of Jagged1 mRNA in astrocyte.As culture duration extended,the expression of Jagged1 mRNA was attenuated significantly(P0.05).Conclusion TGF-β1 can induce the expression of Jagged1 mRNA in the LPS-activated astrocyte,which may inhibit the repair of myelin sheath through the activation of Jagged1/Notch1 pathway.

Key concepts: Astrocyte, Messenger RNA, Transforming growth factor, Chemistry, Cell biology, Molecular biology, Biology, Endocrinology

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