2011•Journal of Nanchang UniversityRequires access
Differential expression of AEs protein in acute injury and protection of cardiomyocytes
Liao Zhang-pinga
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Abstract
It explored the differential expression of AEs proteins in the anoxia/reoxygenation(A/R) injury and anoxia preconditioning(APC) of cardiomyocytes.RT-PCR and Western blotting were used to measure the different AE isoform(AE1,AE2,AE3) mRNA and protein expression in primary neonatal cardiomyocytes A/R model and APC model respectively.The results showed that AE2 protein was upregulated after A/R injury,which can be suppressed by APC.However,APC induced the high level expression of AE1 and AE3 protein.It suggested that AE2 protein may be participate in the A/R injury and AE1,AE3 may be involved in the process of the protection induced by APC.