Effect of electroacupuncture on memory hypofunction of Alzheimer' s Disease rats

Objective: To observe effects of the behaviors of Alzheimer's disease(AD) rats and the activity of superoxide dismutase(SOD),catalase(CAT),the content of malondialdehyde(MDA) in rats' brain tissue and blood serum when apply electroacupuncture(EA) to the points of Shenshu,Fengfu,Zusanli,Sanyinjiao.Methods: To choose 30 healthy male Wistar rats,and divide them into fake surgical operation group,model group and EA group randomly,every group has 10 rats.Model group and EA group injected amyloid protein Aβ1-40 to rats' right side hippocampus to build AD pattern.Fake surgical operation group injected the same dosage of saline in the same position.Model group and fake surgical operation group without any treatment.After two courses treatment,the ability of rats' study and memory in the Y type labyrinth,the activity of SOD and CAT,and the content of MDA in rats' brain tissue and blood serum were determined.Statistical analysis was used.Results: There was no statistically significant in model group and fake surgical operation group before and after treatment;There was statistically significant(P0.05) in EA group compared with model group after treatment.Conclusion: Applying EA to the points of Shenshu,Fengfu,Zusanli and Sanyinjiao,EA could reduce frequency of making AD rats through the test of Y type labyrinth,increase the activities of SOD and CAT,decrease the content of MDA in rats' brain tissue and blood serum.The probably mechanism maybe that EA increased the activity of SOD and CAT's antioxidation system to protect neurone,and strengthened the function of oxyradical's purge system to improve antioxidation ability of body.