2006•Chinese Medical of Factory and MineRequires access
Correlation among the levels of HBV DNA in Serum and the expression of viral markers of hepatic tissue and its pathological lessions in patients with chronic hepatitis B
Ji Yeon Hong
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Abstract
Objective To investigate the relations among the viral markers in serum and hepatocytes and pathological lesions of hepatic tissue and the serum level of HBV DNA in patients with chronic hepatitis B.Methods Ninety patients with chronic hepatitis B were divided into two groups:HBV DNA-negative group and HBV DNA-postive group.HBeAg positive rate in serum,HBsAg and HBcAg expression in hepatic tissue and its pathologicd lesions in the two groups were determined.Results Compared with HBV DNA-negative group,HBV DNA-postive group had higher HBeAg positive rate in serum and had higher expression of HBsAg and HBcAg in hepatic tissue,and there were no difference in inflammation and fibrosis in hepatic tissue of the two groups.Conclusions HBV DNA levels was highly correlated with HBeAg-postive and the expression of HBsAg,and it was not correlated with inflammation and fibrosis in hepatic tissues in patients with chronic hepatitis B.