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2006•Chinese Journal of MisdiagnosticsRequires access

Assessment of P504s(α-methylacy-CoA racemase)Immunohistochemistry in Diagnosis of Prostatic Neoplasms

Hong Du

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Abstract

Objective:To assess the utility of P504s immunohistochemistryin diagnosis of prostatic neoplasms.Methods:Light microscopy and immunohistochemistry examinations(EnVision staining) were performed in 151 cases of prostatic neoplasms to correlate the morphology and protein expression of P504s and prostate specific antigen(PSA).Results:The strong expression of PSA were detected in all of the cases.P504s was strongly and diffusely positive((++)～(+++)) in 21 of 22 cases of prostatic adenocarcinomas.Weak expression was observed in 1 of 127 case of BPH.Both cases of ASAP were negative for P504s.Conclusions:P504s is an useful marker for microscopic diagnosis and differential diagnosis of prostatic neoplasms with the good sensitivity(95.5%) and specificity(99.2%).

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Objective:To assess the utility of P504s immunohistochemistryin diagnosis of prostatic neoplasms.Methods:Light microscopy and immunohistochemistry examinations(EnVision staining) were performed in 151 cases of prostatic neoplasms to correlate the morphology and protein expression of P504s and prostate specific antigen(PSA).Results:The strong expression of PSA were detected in all of the cases.P504s was strongly and diffusely positive((++)～(+++)) in 21 of 22 cases of prostatic adenocarcinomas.Weak expression was observed in 1 of 127 case of BPH.Both cases of ASAP were negative for P504s.Conclusions:P504s is an useful marker for microscopic diagnosis and differential diagnosis of prostatic neoplasms with the good sensitivity(95.5%) and specificity(99.2%).

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Available abstract

Objective:To assess the utility of P504s immunohistochemistryin diagnosis of prostatic neoplasms.Methods:Light microscopy and immunohistochemistry examinations(EnVision staining) were performed in 151 cases of prostatic neoplasms to correlate the morphology and protein expression of P504s and prostate specific antigen(PSA).Results:The strong expression of PSA were detected in all of the cases.P504s was strongly and diffusely positive((++)～(+++)) in 21 of 22 cases of prostatic adenocarcinomas.Weak expression was observed in 1 of 127 case of BPH.Both cases of ASAP were negative for P504s.Conclusions:P504s is an useful marker for microscopic diagnosis and differential diagnosis of prostatic neoplasms with the good sensitivity(95.5%) and specificity(99.2%).

Key concepts: Immunohistochemistry, Medicine, Prostate, Pathology, Differential diagnosis, Staining, Prostate-specific antigen, Antigen

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Assessment of P504s(α-methylacy-CoA racemase)Immunohistochemistry in Diagnosis of Prostatic Neoplasms — Research Paper | ScholarLens