Therapeutic Test of Danofloxacin Liposomes against Artificially Infected Chicken with Mycoplasma gallisepticum

Danofloxacin liposome is a long-acting and lung targeting preparation which is used to treat chronic respiratory disease.Five-day-age health chicklings artificially infected with Mycoplasma gallisepticum(MG) S6 by routes of nasals,eyes and injecting air sac were tested therapeutically.They were randomly divided into six groups,i.e.three danofloxacin liposome tested groups with high,middle and low doses,danofloxacin power group,MG infected and health control groups,forty chicklings per each group.The results indicated that danofloxacin liposome had perfect effect on the MG-infected chickens for 5 days age via drinking water with preparation concentration reached to 100,50,25 mg/L,it could remarkably reduce the antibody positive rate,lower the air-sac lesions,improve the cure,effective and growth rates(P0.01) compared with MG-infected control group.There were significant differences between 100,50 mg/L danofloxacin liposome