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2008•Proceeding of Clinical MedicineRequires access

Effect of rosiglitazone on myocardial ultrastructure of STZ diabetic rats

Sujun Liu

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Abstract

Objective:To investigate the mechanism of heart protective effect of rosiglitazone on diabetic rat heart.Methods:Forty-eight male rats were randomly divided into normal control group(C),diabetic rat group(T)and rosiglitazone treatment group(R).After 8 weeks and 12 weeks,transmission electron microscope were used to examine the myocardial ultrastructure of the rats.And blood glucose,weight,index of heart weight,area of heart cell and C peptide in the blood were measured at the same time.Results:Compared with group C,myocardial mitochondrion were swelled and degenerationed,myofibril were focally dissolved degeneration myocardial fibers arranged irregularly,and fractured in group T and R,pathological changes were aggravated in group T,myocardial pathological changes were alleviated in group R,and reduces obviously along with the treatment course progress.Conclusion:Rosiglitazone may play a protective role in the heart of STZ diabetic rats.

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Objective:To investigate the mechanism of heart protective effect of rosiglitazone on diabetic rat heart.Methods:Forty-eight male rats were randomly divided into normal control group(C),diabetic rat group(T)and rosiglitazone treatment group(R).After 8 weeks and 12 weeks,transmission electron microscope were used to examine the myocardial ultrastructure of the rats.And blood glucose,weight,index of heart weight,area of heart cell and C peptide in the blood were measured at the same time.Results:Compared with group C,myocardial mitochondrion were swelled and degenerationed,myofibril were focally dissolved degeneration myocardial fibers arranged irregularly,and fractured in group T and R,pathological changes were aggravated in group T,myocardial pathological changes were alleviated in group R,and reduces obviously along with the treatment course progress.Conclusion:Rosiglitazone may play a protective role in the heart of STZ diabetic rats.

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Available abstract

Objective:To investigate the mechanism of heart protective effect of rosiglitazone on diabetic rat heart.Methods:Forty-eight male rats were randomly divided into normal control group(C),diabetic rat group(T)and rosiglitazone treatment group(R).After 8 weeks and 12 weeks,transmission electron microscope were used to examine the myocardial ultrastructure of the rats.And blood glucose,weight,index of heart weight,area of heart cell and C peptide in the blood were measured at the same time.Results:Compared with group C,myocardial mitochondrion were swelled and degenerationed,myofibril were focally dissolved degeneration myocardial fibers arranged irregularly,and fractured in group T and R,pathological changes were aggravated in group T,myocardial pathological changes were alleviated in group R,and reduces obviously along with the treatment course progress.Conclusion:Rosiglitazone may play a protective role in the heart of STZ diabetic rats.

Key concepts: Rosiglitazone, Internal medicine, Medicine, Diabetes mellitus, Endocrinology, Ultrastructure, Pathological, Myofibril

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