ScholarLens Back to search
2007•Zhongguo xunhuan zazhiRequires access

Between Aldosterone Synthase Gene Polymorphism and Pedigreed Primary Hypertension

Yingxin Zhao

Open publisher page 0 citations

Abstract

Objective:To investigate the frequency of variant aldosterone synthase(CYP11B2)gene and its relation to pedigreed primary hypertension.Methods:A pedigree based case-control study was conducted using PCR-RELP techniques to explore the relation between aldosterone synthase gene polymorphism and primary hypertension of 276 subjects in 65 pedigrees.Results:There was a significant difference in TT gene type between hypertension group and nomortension group(P0.01).There were significant differnces in TT gene type between each generation of both groups(P0.01).There were significant differnces in T allele between each generation of both groups(P0.01).Conclusion :There was significant difference in the distribution of T-allele frequency of CYP11B2 gene between primary hypertension pedigrees and normotension pedigrees.T-allele may be one of inherited markers of pedigreed primary hypertension.

About this research paper

What this paper is about

Objective:To investigate the frequency of variant aldosterone synthase(CYP11B2)gene and its relation to pedigreed primary hypertension.Methods:A pedigree based case-control study was conducted using PCR-RELP techniques to explore the relation between aldosterone synthase gene polymorphism and primary hypertension of 276 subjects in 65 pedigrees.Results:There was a significant difference in TT gene type between hypertension group and nomortension group(P0.01).There were significant differnces in TT gene type between each generation of both groups(P0.01).There were significant differnces in T allele between each generation of both groups(P0.01).Conclusion :There was significant difference in the distribution of T-allele frequency of CYP11B2 gene between primary hypertension pedigrees and normotension pedigrees.T-allele may be one of inherited markers of pedigreed primary hypertension.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective:To investigate the frequency of variant aldosterone synthase(CYP11B2)gene and its relation to pedigreed primary hypertension.Methods:A pedigree based case-control study was conducted using PCR-RELP techniques to explore the relation between aldosterone synthase gene polymorphism and primary hypertension of 276 subjects in 65 pedigrees.Results:There was a significant difference in TT gene type between hypertension group and nomortension group(P0.01).There were significant differnces in TT gene type between each generation of both groups(P0.01).There were significant differnces in T allele between each generation of both groups(P0.01).Conclusion :There was significant difference in the distribution of T-allele frequency of CYP11B2 gene between primary hypertension pedigrees and normotension pedigrees.T-allele may be one of inherited markers of pedigreed primary hypertension.

Key concepts: Aldosterone synthase, Pedigree chart, Aldosterone, Allele, Gene, Essential hypertension, Genetics, Medicine

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Between Aldosterone Synthase Gene Polymorphism and Pedigreed Primary Hypertension — Research Paper | ScholarLens