2002•Henan yixue yanjiuRequires access

Effect of antisense oligonucleotide against hTR on the telomerase activity and apoptosis in Hep-2 cells

Jie Hu

Abstract

Objective: To study the imhibitory effect of human telomerase activity by an antisense oligonucleotide against human telomerase RNA(hTR RNA) in Hep 2 cells.Methods: Telomerase activity of Hep 2 cells with antisense treatment was measured using the TRAP assay.Results: The telomerase activity was effectively inhibited by the antisense treatment.Conclusion: Antisense oligonucleotide against hTR can effectively inhibit the telomerase activity of tumor cells and subject is an effective and novel approach for treatment of malignant cancers.

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Key concepts: Telomerase, Oligonucleotide, RNA, Antisense RNA, Molecular biology, Apoptosis, Sense (electronics), Cancer research