Effect of High-Dose Methylprednisolone Pulse Therapy on Acute Demyelinating Encephalopathy

Objective To investigate the clinical effect of high-dose methylprednisolone pulse therapy on acute demyelinating encephalopathy.Method 54 patients were divided into 2 groups: treatment group(30 patients) and control group(24 patients).Patients in the treatment group received intravenous drop infusion with methylprednisolone(1000 mg/d) for 3 to 5 days.After the treatment,patients were then provided with dehydrocortisone(60 mg/d) for 1 day,and the dosage was gradually reduced until discontinuation.Control subjects were treated with normal dose of dehydrocortisone(20～40 mg/d) for 3 to 5 days,and the dosage was gradually reduced until discontinuation.Result The percentage efficacy in the treatment group(90%) was significantly higher than the control group(66.7%,X2=3.871,P0.05).The percentage of patients with adverse effect in the treatment group(13.3%) was significantly lower than the control group(33.3%,X2=3.749,P0.05).Conclusion High-dose of methylprednisolone pulse therapy is safe and effective for the treatment of acute demyelinating encephalopathy.