The effect of neoadjuvant chemotherapy for breast cancer and its influencing factors

Objective To investigate the clinicopathological features of neoadjuvant chemotherapy treatment for breast cancer,the treatment effect and efficacy of influencing factors.Methods All of 78 cases of breast cancer patients with ET regimen of preoperative neoadjuvant chemotherapy,preoperative efficacy evaluation,and analysis of relevant factors.Results Clinical evaluation of CR 21 cases,PR 42 cases,SD 15 cases,PD 0 cases,the effective rate was 80.77%(63/78).pCR rate was 19.23%.Histological grade was related with clinical effectively(P 0.05),and has related with pCR(P 0.05),tumor grade,lymph node status,and molecular subtype,and clinically effective and pCR.Tumor stage,lymph node status and molecular subtypes the independent impact factors of breast cancer neoadjuvant chemotherapy clinical efficacy(P 0.05);histological grade,lymph node status and molecular subtypes were the independent impact factors of breast cancer neoadjuvant chemotherapy histopathological efficacy(P 0.05).Conclusion The high clinical efficacy of neoadjuvant chemotherapy,histological grade,tumor stage,lymph node status and molecular subtypes are the independent factors to affect breast cancer response to neoadjuvant chemotherapy.