Clinical significance of tumor markers in neoadjuvant chemotherapy of breast cancer.

Objective To explore the expression and its clinical significance of tumor markers in breast cancer tissue received neoadjuvant chemotherapy.Methods The ER,PR,c-erbB2,Ki67 in breast cancer tissue of 89 patients received neoadjuvant chemotherapy were detected by immunohistochemical method,and analysed the relation to tumor markers with response of neoadjuvant chemotherapy.Results The overall response rate of neoadjuvant chemotherapy on breast cancer was 89.9%,of which the complete response was 32.6%,partial response was 57.3%,pathological complete response was 17.9%,disease stable 10.5%.Hormonal receptor expression was significantly related to treatment response(P0.05).No correlation was observed between the treatment response and c-erB2,Ki67 expression.Conclusion There is higher sensitivity in neoadjuvant chemotherapy hormonal receptor negative tumors.The tumor markers of breast cancer in neoadjuvant chemotherapy may be provide important index in decision sensation of chemotherapy and clinical evaluation.