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Analysis of Geniposide and Total Nitrogen Content in Qingkailing Injection Intermediate by Near Infrared Spectroscopy and Synergy Interval Partial Least Squares

Xiang Zhu

Open publisher page 4 citations

Abstract

Near infrared spectrometry combined with chemometric methods was used for establishing a new method to determine the content of total nitrogen and geniposide in Qingkailing injections.The training and testing sets are partitioned by Kernard-Stone algorithm.Synergy interval partial least squares(siPLS) is used for selecting effective spectral regions and building the quantitative calibration models of the total nitrogen and geniposide.Pre-treatments of spectra are discussed in detail.Correlation coefficient obtained is 0.999,RMSECV is 0.023,RMSEP is 0.074 for the total nitrogen,and correlation coefficient is 0.708,RMSECV is 0.023,RMSEP is 0.159 for geniposide,respectively.The predictive results show that the proposed method is rapid,non-destructive and credible,which can be applied to control the quality of Chinese medicine injection online in industry scenes extensively.

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What this paper is about

Near infrared spectrometry combined with chemometric methods was used for establishing a new method to determine the content of total nitrogen and geniposide in Qingkailing injections.The training and testing sets are partitioned by Kernard-Stone algorithm.Synergy interval partial least squares(siPLS) is used for selecting effective spectral regions and building the quantitative calibration models of the total nitrogen and geniposide.Pre-treatments of spectra are discussed in detail.Correlation coefficient obtained is 0.999,RMSECV is 0.023,RMSEP is 0.074 for the total nitrogen,and correlation coefficient is 0.708,RMSECV is 0.023,RMSEP is 0.159 for geniposide,respectively.The predictive results show that the proposed method is rapid,non-destructive and credible,which can be applied to control the quality of Chinese medicine injection online in industry scenes extensively.

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Available abstract

Near infrared spectrometry combined with chemometric methods was used for establishing a new method to determine the content of total nitrogen and geniposide in Qingkailing injections.The training and testing sets are partitioned by Kernard-Stone algorithm.Synergy interval partial least squares(siPLS) is used for selecting effective spectral regions and building the quantitative calibration models of the total nitrogen and geniposide.Pre-treatments of spectra are discussed in detail.Correlation coefficient obtained is 0.999,RMSECV is 0.023,RMSEP is 0.074 for the total nitrogen,and correlation coefficient is 0.708,RMSECV is 0.023,RMSEP is 0.159 for geniposide,respectively.The predictive results show that the proposed method is rapid,non-destructive and credible,which can be applied to control the quality of Chinese medicine injection online in industry scenes extensively.

Key concepts: Partial least squares regression, Correlation coefficient, Coefficient of determination, Chemistry, Analytical Chemistry (journal), Calibration, Near-infrared spectroscopy, Nitrogen

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Analysis of Geniposide and Total Nitrogen Content in Qingkailing Injection Intermediate by Near Infrared Spectroscopy and Synergy Interval Partial Least Squares — Research Paper | ScholarLens