2008•Journal of Shanxi Medical College for Continuing EducationRequires access
Expressions and Significance of TNF-α and CGRP in the Intestinal Tissues of Portal Hypertension in Rats
Meng Junpeng
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Abstract
Objective:To observe the expressions of tumor necrosis factor-α(TNF-α) and calcitonin gene-related peptide(CGRP) of the intestinal tissues of portal hypertension in rats and investigate the significance in portal hypertensive enteropathy on the model of portal hypertension in rats.Methods: Male SD rats were randomly divided into a experimental group and a control group.The SD rats in the experimental group were performed by the two-stage ligation of portal vein plus ligation of the left adrenal vein and the portal vein pressure was measured in two weeks after complete portal ligation.The expressions of TNF-α and CGRP in intestinal tissues were observed by immunohistochemistry.Results: The portal vein pressure of rats in the experimental group was significantly higher than that in the control group(P0.05).TNF-α and CGRP of the intestinal tissues of rats in the experimental group were strongly positive expression,but those in the control group were negative or weakly positive expression.Conclusion: TNF-α and CGRP play a certain role in the intestinal mucosa lesions of portal hypertension.