Effects of Tibetan drugs on change of SaO_2 of young men after step-test at high altitude

Objective: To seek for a new method against hypoxia and to validate the effects of two compound drugs on change of SaO_2 of young men after step-test at high altitude.Methods: 96 young male subjects were divided randomly into three groups,and they were given Luobusang capsule,Di′ao Xinxuekang capsule and placebo,respectively.A single blind procedure was used.Before three days and after five days exposed to high altitude(above sea level 3680 m),they took different drugs according to their group,2 capsule each time,three time a day for 8 days.At the fifth day after they entered high altitude,their rest SaO_2 and SaO_2 during recovery phase after they finished the step-test at 0 min,1 min,2 min,3 min and 5 min were measured,respectively.Results: Comparing with before stepping,SaO_2 during recovery phase decreased significantly in Luobusang group and Di′ao Xinxuekang group at 0 min and 1 min(P0.05 or 0.01).Comparing with placebo group,the rest SaO_2 in both Luobusang group and Di′ao Xinxuekang group increased significantly.Meanwhile,it was higher significantly than that of the placebo group the SaO_2 during recovery phase of Di′ao Xinxuekang group at 0 min and 1 min(P0.05 or 0.01).Conclusion: The two drugs have effective role in prevention of SaO_2 decrease of young men exposed into high altitude.Di′ao Xinxuekang has an obvious effect on change of SaO_2 after step-test.Abstract:Objective: To seek for a new method against hypoxia and to validate the effects of two compound drugs on change of SaO2of young men after step-test at high altitude.Methods:96 young male subjects were divided randomly into three groups,and they were given Luobusang capsule,Di′ao Xinxuekang capsule and placebo,respectively.A single blind procedure was used.Before three days and after five days exposed to high altitude(above sea level 3680 m),they took different drugs according to their group,2 capsule each time,three time a day for 8 days.At the fifth day after they entered high altitude,their rest SaO2and SaO2during recovery phase after they finished the step-test at 0 min,1 min,2 min,3 min and 5 min were measured,respectively.Results:Comparing with before stepping,SaO2during recovery phase decreased significantly in Luobusang group and Di′ao Xinxuekang group at 0 min and 1 min(P0.05 or 0.01).Comparing with placebo group,the rest SaO2in both Luobusang group and Di′ao Xinxuekang group increased significantly.Meanwhile,it was higher significantly than that of the placebo group the SaO2during recovery phase of Di′ao Xinxuekang group at 0 min and 1 min(P0.05 or 0.01).Conclusion:The two drugs have effective role in prevention of SaO2decrease of young men exposed into high altitude.Di′ao Xinxuekang has an obvious effect on change of SaO2after step-test.