2016•Indian Journal of Small Ruminants (The)Requires access
Gastrointestinal Nematode-Induced Modulation of Albendazole Biotransformation in Goats
P.K. Sanyal, D. Rawte, Archana E. Kerketta, N.K. Kumbhakar, Dinesh Kumar, Shantanu Pal, K.R. Baghel, Savita Bisen
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Abstract
The influence of subclinical nematodosis on kinetic disposition of albendazole (ABZ) was evaluated in goats following intraruminal administration of the drug. Plasma levels of albendazole sulphoxide (ABZ-SO) was significantly (P<0.05) higher in goats with zero epg (eggs per g) of faeces. Pharmacokinetic analysis of data revealed significantly (P<0.05) higher concentration maximum (Cmax), time to reach Cmax(Tmax) and area under the concentration-time curve (AUC) in goats with zero epg of faeces, while significantly (P<0.05) lower bioavailability of ABZ-SO could be observed in goats with <2000 and >2000 epg of faeces. Extrapolation of data of the active metabolite ABZ-SO levels in terms of drug-parasite contact with different levels of parasitism revealed that the parasites are exposed to the lethal toxic levels for a lesser duration following intraruminal administration of the drug in goats with subclinical nematodosis.