ScholarLens Back to search
1995•Chinese Journal of PharmaceuticalsRequires access

STUDY ON DRUGS AGAINST HYDATIDOSIS:SYNTHESIS OF METABOLITES AND ANALOGUES OF ALBENDAZOLE

Li Huang

Open publisher page 1 citations

Abstract

Twenty-five metabolites and analogues of albendazole were synthesized for screening drugs against Echinococcus granulosus cysts in mice and their biological activities were compared.The results of preliminary screening tests showed that compounds 4,5,7,8,11,13,and 20 exhibited better effects against hydatidosis in mice.Among them,albendazole sulfoxide(13)was more effective than the others including albendazole even administered at a half dose of the latter.Nevertheless,an other major metabolite,albendazole sulfone,possessed no effect.

About this research paper

What this paper is about

Twenty-five metabolites and analogues of albendazole were synthesized for screening drugs against Echinococcus granulosus cysts in mice and their biological activities were compared.The results of preliminary screening tests showed that compounds 4,5,7,8,11,13,and 20 exhibited better effects against hydatidosis in mice.Among them,albendazole sulfoxide(13)was more effective than the others including albendazole even administered at a half dose of the latter.Nevertheless,an other major metabolite,albendazole sulfone,possessed no effect.

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Twenty-five metabolites and analogues of albendazole were synthesized for screening drugs against Echinococcus granulosus cysts in mice and their biological activities were compared.The results of preliminary screening tests showed that compounds 4,5,7,8,11,13,and 20 exhibited better effects against hydatidosis in mice.Among them,albendazole sulfoxide(13)was more effective than the others including albendazole even administered at a half dose of the latter.Nevertheless,an other major metabolite,albendazole sulfone,possessed no effect.

Key concepts: Albendazole, Echinococcus granulosus, Chemistry, Metabolite, Pharmacology, Echinococcosis, Chromatography, Biochemistry

Back to paper searchBrowse research topicsOriginal source
STUDY ON DRUGS AGAINST HYDATIDOSIS:SYNTHESIS OF METABOLITES AND ANALOGUES OF ALBENDAZOLE — Research Paper | ScholarLens