A randomized control study of lamivudine on chronic hepatitis B

Objective To observe the effect of lamivudine in the treatment of chronic hepatitis B.Methods 322 patients with chronic hepatitis B were divided into the treatment group and the control group by a randomized controlled way.Patients in the treatment group and the control group were treated with lamivudine(100 mg/d) with placebo(100mg/d) for 52 weeks,respectively.The changes of clinical symptoms,signs,liver function and virology indexes were compared in two groups.Results Commpared with the control group,the treatment time extent,ALT,AST and HBV DNA level in the treatment group gradually reduced,with a statistically significant difference.The treatment group's HBeAg shade rate(80.67%),HBsAg shade rate(20.12%),HBeAg conversion rate(61.11%) were all higher than those in the control group(6.96%,27.50%,27.50%).Conclusion Lamivudine therapy has the positive effect on chronic hepatitis B patients in the short term,while the long-term efficacy still need further study.