Acute toxic effects of lead acetate on mice

【Objective】This study aimed to investigate the acute toxic effects of lead acetate on mice so as to ensure the mechanism and target organs of lead acetate on mice.【Method】Mice were orally administered with different dosages of lead acetate to detect the median lethal dose(LD50)by Bliss method.Then,mice were randomly divided into 4groups and fed with deionized water solutions with different doses of lead acetate(0mmol/L(control group),2.4mmol/L(low dosage group),4.8mmol/L(median dosage group),and 9.6mmol/L(high dosage group))for 9days.The weights of mice were recorded on the 0th day and the 9th day,and cerebrums,hearts,lungs,livers,spleens,kidneys of mice were collected and weighed.The organ relative indexes were calculated,and histopathological examination was conducted as well.【Result】The LD50 of lead acetate to mice was 10 562mg/kg.The body weight gain of mice was not significantly related to the dosage of lead acetate.Compared to the control group,kidney relative index of mice increased significantly in low dosage group(P0.05),and increased highly significantly in the other two dosage groups(P0.01).The relative indexes of the rest organs were not significantly different between the control group and dosage groups(P0.05).The tissues of mice in dosage groups had pathological changes,especially in the high dosage group.【Conclusion】Lead acetate had low intensity toxic to mice.It had certain acute toxic effects on tissues of mice,and the histopathological changes were particularly significant.