2007•Zhongguo redai yixueRequires access
Experimental observation on the mechanism and effection of Qishuheji on bleomycin-induced pulmonary fibrosis in rats
Liu En-shun
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Abstract
Objective To investigate the effect and mechanism of QiZhuHeJi(QZHJ)on bleomycin-induced pulmonary fibrosis in rats.Methods Sixty rats were divided into four groups randomly,including a normal control group,model group treated with bleomycin,QZHJ treated group,and hydrocortisone treated group.The rats were treated by single intratracheal instillation of bleomycin,and each group was given corresponding drugs respectively.The experimental rats were sacrificed in batch on the 3rd,7th and 21st day for observing the expression of TGF-β1 and HA,counting the total number of cells inside the BALF and the its differential count.Results The expression of TGF-β1 in model group on the 3rd,7th and 21st day was obviously increased than that of normal control group(P0.01).The expression of TGF-β1 in QZHJ group was lower than those of model group,higher than that of hydrocortisone group on the 3rd day and apparently lower than that of hydrocortisone group.Conclusion The QZHJ has a notable effect in bleomycin induced pulmonary fibrosis rats,inhibition of TGF-β1 expression is one of its possible mechanisms.