The clinical research of Risperidone combined Mirtazapine in the treatment of negative symptoms of schizophrenia in 68 patients

Objective:To evaluate clinical efficacy and safety of Risperidone combined Mirtazapine in the treatment of negative symptoms of schizophrenia.Methods:136 patients with predominantly negative symptoms of schizophrenia were randomly divided into study group(Risperidone combined Mirtazapine) and the control group(Risperidone alone) with10 weeks' treatment.PANSS and TESS assessed the efficacy and safety respectively.Results: After treatment,PANSS scores were significantly lower before treatment(P0.05).4,6,8,10 week after treatment,the negative factor scores of study group were significantly lower than the control group,the difference was significant(P0.05 or P0.01).Two groups of adverse events were mild to moderate.Conclusions: Risperidone combined Mirtazapine in the treatment of schizophrenia with negative symptoms of rapid onset,better efficacy,fewer side effects,and good patient compliance.