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Effect of 17β-estradiol on the expression of brain-derived neurotrophic factor and neurotrophin-3 in the hippocampus of ovariectomized mice

Zhang Yong

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Abstract

AIM To confirm the possible neurotrophomodulatory effect of estrogens. METHODS Western blot analysis was employed to determine the levels of brain-derived neurotrophic factor(BDNF) and neurotrophin 3(NT-3). RESULTS There was a significant reduction of BDNF expression in the hippocampus of ovariectomized mice compared with that of sham-operated mice (P0.01). Replacement of 17β-estradiol(2.4 or 4.8 μg·d -1, sc, for 12 weeks) restored BDNF level in the hippocampus. However, both ovariectomy and estradiol replacement had no effect on NT-3 expression in the hippocampus. CONCLUSION The decrease in the expression of BDNF in the hippocampus of ovariectomized mice is closely associated with estrogen deficiency. Estrogen plays an important role in modulating BDNF level in the hippocampus.

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AIM To confirm the possible neurotrophomodulatory effect of estrogens. METHODS Western blot analysis was employed to determine the levels of brain-derived neurotrophic factor(BDNF) and neurotrophin 3(NT-3). RESULTS There was a significant reduction of BDNF expression in the hippocampus of ovariectomized mice compared with that of sham-operated mice (P0.01). Replacement of 17β-estradiol(2.4 or 4.8 μg·d -1, sc, for 12 weeks) restored BDNF level in the hippocampus. However, both ovariectomy and estradiol replacement had no effect on NT-3 expression in the hippocampus. CONCLUSION The decrease in the expression of BDNF in the hippocampus of ovariectomized mice is closely associated with estrogen deficiency. Estrogen plays an important role in modulating BDNF level in the hippocampus.

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Available abstract

AIM To confirm the possible neurotrophomodulatory effect of estrogens. METHODS Western blot analysis was employed to determine the levels of brain-derived neurotrophic factor(BDNF) and neurotrophin 3(NT-3). RESULTS There was a significant reduction of BDNF expression in the hippocampus of ovariectomized mice compared with that of sham-operated mice (P0.01). Replacement of 17β-estradiol(2.4 or 4.8 μg·d -1, sc, for 12 weeks) restored BDNF level in the hippocampus. However, both ovariectomy and estradiol replacement had no effect on NT-3 expression in the hippocampus. CONCLUSION The decrease in the expression of BDNF in the hippocampus of ovariectomized mice is closely associated with estrogen deficiency. Estrogen plays an important role in modulating BDNF level in the hippocampus.

Key concepts: Ovariectomized rat, Hippocampus, Internal medicine, Endocrinology, Brain-derived neurotrophic factor, Neurotrophic factors, Estrogen, Neurotrophin

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Effect of 17β-estradiol on the expression of brain-derived neurotrophic factor and neurotrophin-3 in the hippocampus of ovariectomized mice — Research Paper | ScholarLens