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[Expression of brain-derived neurotrophic factor in hippocampus of ovariectomized mouse].

Dahua Lu, De-sen Yang, Dan Liu, Chang-Qi Li, Xuegang Luo

Abstract

OBJECTIVE: To explore the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus after ovariectomy in mice. METHODS: BDNF levels were detected by immunohistochemistry combined image analysis in hippocampal CA regions and dentate gyrus of ovariectomized mice. RESULTS: The expression of BDNF in hippocampus of mice decreased significantly after the ovariectomy after 4 days. The recovery BDNF expression started 14 days after the ovariectomy and after 28 days, the expression of BDNF in hippocampus recovered to the normal level. CONCLUSION: The decrease of estrogen in ovariectomized mice can weaken the expression of BDNF in hippocampus during the early stage.

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Key concepts: Ovariectomized rat, Hippocampus, Dentate gyrus, Brain-derived neurotrophic factor, Internal medicine, Neurotrophic factors, Hippocampal formation, Endocrinology