Current research status on the virulence of common pathogenic Candida

Objective With the application of chemotherapy for malignant tumors and immunosuppressive drugs,we found that more patients were experiencing Candida infection.The selective pressure of the antifungal drugs resulted in the increasing proportion of non Candida albicans and Candida albicans.Candida albicans and Candida tropicalis have the strongest virulence in clinically common pathogenic Candida.The pathogenicity of Candida is not decided by a single factor,but by a group of factors,including the dimorphic transition,hydrophobicity,adhesion,phospholipase activity,aspartic proteinase activity,and hemolysis,etc..Candida albicans virulence factors and pathogenic mechanism are very complicated.The understanding of the pathogen's pathogenicity will contribute to the prevention and treatment of Candida infection.