Correlation between the change of serum Hcy and carotid atherosclerosis of hypertension coronary heart disease patients

Objective To investigate the relativity between the serum total homocysteine(Hcy) level and the carotid atherosclerosis degree of hypertension coronary heart disease patients.Methods 30 patients with hypertension,30 patients with coronary heart disease(CHD),30 patients with hypertension and coronary heart disease,and 30 healthy individuals were allocated to detect the serum total Hcy levels by applying enzymatic cycle method and ascertain whether they were suffering from carotid atherosclerosis with color Doppler ultrasound.Results the serum total Hcy levels of hypertension coronary heart disease group,CHD group and hypertension group were significantly higher than the normal control group(P0.01).The detection rates of carotid atherosclerosis of hypertension coronary heart disease group,CHD group and hypertension disease group were higher than the incidence rate of the normal control group(P0.01).The serum total homocysteine(Hcy) levels and the incidence rate of carotid atherosclerosis of hypertension coronary heart disease group were all higher than hypertension group and the CHD group(P0.05).Conclusion This study shows that patients with hypertension coronary heart disease have higher serum total Hcy levels and higher incidence rates of carotid atherosclerosis.